Oxcarbazepine Induced Maculopapular Rash - A Case Report
Published: January 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.5375
Arunava Biswas , Ritabrata Mitra, Sukanta Sen, Agnik Pal, Santanu Kumar Tripathi
1. Post Doctoral Trainee, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, 108, C.R. Avenue, Kolkata, India.
2. Assistant Professor, Department of Pulmonary Medicine, Institute of Post Graduate Medical Education & Research, Circus Ave, Bhawanipur, Kolkata, India.
3. Post Doctoral Trainee, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, 108, C.R. Avenue, Kolkata, India.
4. Post Graduate Trainee, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, 108, C.R. Avenue, Kolkata, India.
5. Professor and HOD, Department of Clinical & Experimental, Pharmacology, Calcutta School of Tropical Medicine, 108, C.R. Avenue, Kolkata, India.
Correspondence
Dr. Arunava Biswas,
Ganga-505, Godrej Prakriti, 187F/1 B.T.Road, Sodepur, Kolkata-7000115, India.
Phone : 9674328329, E-mai : drabiswas@gmail.com
Unlike carbamazepine, newer anti epileptic drug like oxcarbazepine, reports fewer side effects. In this report we describe a case of oxcarbazepine induced maculopapular rash probably happened because of a drug interaction with isoniazid, and a brief review of the existing literature is presented herewith. A 40-year-old male patient received oxcarbazepine 300mg twice daily along with other anti-tubercular drugs including isoniazid (300mg) once daily since two days. Extensive cutaneous rash with intense itching developed which subsided on discontinuation of oxcarbazepine. This case highlights the fact that there is a potential possibility of drug-drug interaction between oxcarbazepine and isoniazid and concomitant use of these two drugs should better be avoided during clinical practice.
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